Michael Webb
Associate Professor of Chemistry
ISC 327C
585-245-5675
mwebb@geneseo.edu
he/him
Dr. Michael Webb has been a member of the Geneseo faculty since 2022.
Research Interests
Research within the Webb group focuses on the occurrence of metals in medicine as either the therapeutic agent or the target for therapy. Specifically, protein interactions have been observed to be central in either the pathology of several diseases following an interactions with endogenous metal ions, thereby becoming the target for therapy, or in the transportation of metallotherapeutics to their site of action. The projects we are currently investigating are: (1) the use of ruthenium-based therapeutics for the treatment of Alzheimer鈥檚 disease, (2) ruthenium complexes as antibacterial agents, and (3) the interactions between metal ions and the Parkinson鈥檚 disease protein. For more information on these projects, please visit my personal research webpage: https://webb-lab.weebly.com/
Office Hours
Curriculum Vitae
Education
Postdoctoral Researcher, University of California Berkeley, Berkeley, CA.
Ph.D. Chemistry, Simon Fraser University, Burnaby, BC.
B.Sc. Chemistry (Honours), Mount Allison University, Sackville, NB.
Publications
Geneseo Student Co-authors are in听bold
11.听Murphy, B.J.鈥�;听Bollinger, T.A.鈥�; Dagar, M.;听Hacker, R.M.; Oskard, S.M.; Brennessel, W.W.; Webb, M.I. 鈥淭wo Perfectly Cromulent Ferrocene Containing Ruthenium(II)-arene Antibacterial Agents鈥澨�Canadian Journal of Chemistry,听2025, In Press (鈥� = each author contributed听equally to this work).
10.听Hacker, R.M.;听Smith, J.J.; Platt, D.C.; Jones, M.A.; Brennessel, W.W.; Webb, M.I. 鈥淩uthenium(II)-Arene Complexes with a 2,2′-Bipyridine Ligand as Anti-A尾 Agents鈥澨�Biomolecules,听2025, 15, 475.
9.听Hacker, R.M.;听Grimard, D.M.;听Morgan, K.A.; Saleh, E.; Wrublik, M.M.; Meiss, C.J.; Kant, C.C.; Jones, M.A.; Brennessel, W.W.; Webb, M.I. “Ru(ii)鈥揳rene azole complexes as anti-amyloid-尾 agents”听Dalton Transactions,听2024, 53, 18845-18855.
8. Ehlbeck, J.T.;听Grimard, D.M.;听Hacker, R.M.; Garcia, J.A.; Wall, B.J.; Bothwell, P.J.; Jones, M.A.; Webb, M.I. “Finding the Best Location: Improving the Anti-Amyloid Ability of Ruthenium(III) Complexes with Pyridine Ligands”听Journal of Inorganic Biochemistry,听2024, 250, 112424.
7. Webb, M.I. (2023). The Design of Metal Complexes to Target the Amyloid-尾 Peptide in Alzheimer’s Disease. In Encyclopedia of Inorganic and Bioinorganic Chemistry, R.A. Scott (Ed.).
6. Mensah, S.; Rosenthal, J.D.; Dagar, M.; Brown, T.; Mills, J.J.; Hamaker, C.G; Ferrence, G.M.; Webb, M.I. 鈥淎 Ru(II)-Arene-Ferrocene Complex With Promising Antibacterial Activity鈥澨�Dalton Transactions,听2022, 51, 17609-17619.
5. Yawson, G.K.; Will, M.F.; Huffman, S. E.; Strandquist, E.T.; Bothwell, P.J.; Oliver, E.B.; Platt, D.C.; Apuzzo, C.F.; Weitzel, C.S.; Jones, M.A.; Ferrence, G.M.; Hamaker, C.G.; Webb, M.I. 鈥淎 Dual-Pronged Approach: A Ruthenium(III) Complex That Modulates Amyloid-尾 Aggregation and Disrupts Its Formed Aggregates鈥澨�Inorganic Chemistry,听2022, 61, 2733-2744.
4. Meiss, C.J.; Bothwell, P.J.; Webb, M.I. 鈥淩uthenium(II)-Arene Complexes With Chelating Quinoline Ligands As Anti-Amyloid Agents鈥澨�Canadian Journal of Chemistry,听2022, 100, 18-24.
3. Wall, B.J.鈥�; Will, M.F.鈥�; Yawson, G.K.; Bothwell, P.J.; Platt, D.C.; Apuzzo, C.F.; Jones, M.A.; Ferrence, G.M.; Webb, M.I. 鈥淭he Importance of Hydrogen Bonding: Structure-Activity Relationships of Ruthenium(III) Complexes for Alzheimer鈥檚 Disease Therapy with Pyridine-based Ligands鈥澨�Journal of Medicinal Chemistry,听2021, 64, 10124-10138 (鈥� = each author contributed equally to this work)
2. Yawson, G.K.; Huffman, S.E.; Fisher, S.S.; Bothwell, P.J.; Platt, D.C.; Jones, M.A.; Hamaker, C.G.; Ferrence, G.M.; Webb, M.I. 鈥淩uthenium(III) Complexes with Imidazole Ligands That Modulate the Aggregation of the Amyloid-尾 Peptide Via Hydrophobic Interactions鈥澨�Journal of Inorganic Biochemistry,听2021, 214, 111303.
1. Huffman, S.E.鈥�; Yawson, G.K.鈥�; Fisher, S.S.; Bothwell, P.J.; Platt, D.C.; Jones, M.A.; Hamaker, C.G; Webb, M.I. 鈥淒etermining Structure Activity Relationships for Ruthenium(III) Complexes Containing Thiazole-based Ligands for Their Ability to Prevent Amyloid-Beta Aggregation鈥澨�Metallomics,听2020, 12, 491-503. Featured on the back cover. (鈥� = each author contributed equally to this work)